منابع مشابه
Pharmacology of oleanolic acid and ursolic acid.
Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human li...
متن کاملDetermination of Ursolic Acid and Ursolic Acid Lactone in the Leaves of Eucalyptus tereticornis by HPLC
Um método simples, isocrático, de HPLC foi desenvolvido para quantificação simultânea de dois triterpenos bioativos, ácido ursólico e lactona do ácido ursólico em folhas de E. tereticornis. As amostras foram analisadas em coluna RP-18 (4,6 × 250 mm, 5 μm) com metanol e água acidificada a pH 3,5 com TFA (88:12) a 210 nm. O método foi validado e aplicado para a quantificação simultânea dos triter...
متن کاملSynthesis and antiangiogenic activity of novel gambogic acid derivatives.
Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity. Derivatives 4, 32, 35, 36 effectively suppressed the formation of newly grown blood vessels and showed lower toxicities than GA as evaluated by zebrafish heart ra...
متن کاملUrsolic Acid Inhibits Nuclear Factor-
The process of tumorigenesis requires cellular transformation, hyperproliferation, invasion, angiogenesis, and metastasis. Several genes that mediate these processes are regulated by the transcription factor nuclear factorB (NFB). The latter is activated by various carcinogens, inflammatory agents, and tumor promoters. Thus, agents that can suppress NFB activation have the potential to suppress...
متن کاملSynthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues.
More than 40% of the World population is at risk of contracting malaria, which affects primarily poor populations in tropical and subtropical areas. Antimalarial pharmacotherapy has utilised plant-derived products such as quinine and artemisinin as well as their derivatives. However, worldwide use of these antimalarials has caused the spread of resistant parasites, resulting in increased malari...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Integrative Cancer Therapies
سال: 2010
ISSN: 1534-7354,1552-695X
DOI: 10.1177/1534735410367647